Water → HCID 21698925, 화합물

HRID 1597185노트

반응식

HRID 1597185 반응식
[F:1][C:2]1[C:12]([N:13]2[C:21](=[O:22])[C:20]3[CH2:19][CH2:18][CH2:17][CH2:16][C:15]=3[C:14]2=[O:23])=[C:11]([N+:24]([O-])=O)[C:5]2[NH:6][C:7](=[O:10])[CH2:8][O:9][C:4]=2[CH:3]=1.O>C(O)(=O)C.[Fe]>[NH2:24][C:11]1[C:5]2[NH:6][C:7](=[O:10])[CH2:8][O:9][C:4]=2[CH:3]=[C:2]([F:1])[C:12]=1[N:13]1[C:21](=[O:22])[C:20]2[CH2:19][CH2:18][CH2:17][CH2:16][C:15]=2[C:14]1=[O:23]

참가 물질

5

반응물 2

HCID 962WaterHCID 21698918HCID 21698918, 화합물

생성물 1

HCID 21698925HCID 21698925, 화합물수율 104.7%

시약·촉매·용매 2

HCID 23925Iron촉매HCID 176Acetic Acid용매

실험 절차

2-[7-Fluoro-5-nitro-2H-1,4-benzoxazine-3(4H)-on-6-yl]-4,5,6,7-tetrahydro-2H-isoindole-1,3-dione (1.25 g) was dissolved in acetic acid (13 ml) and iron powder (0.77 g) was added with stirring. Solution was stirred at ambient temperature for 12 hr and water was added. Product was extracted with ethyl acetate to afford the title compound (1.2 g).

후처리

  1. stirringSolution was stirred at ambient temperature for 12 hr
  2. extractionProduct was extracted with ethyl acetate

출처 및 근거

ORD 기록
ord-8fa45bbf7e774577af0afe6034ac7418
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06294503B1

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