Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Cyanide → 1'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Cyanide | HCID 8929 | — |
| 반응물 | 1-Benzyl-4-piperidone | HCID 19220 | — |
| 반응물 | Piperidine, hydrochloride (1:1) | HCID 2723721 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile | HCID 2733434 | 95.4% |
반응 단계
12.16 g of piperidine hydrochloride and 18.9 g of 1-benzylpiperid-4-one are dissolved in 50 ml of an MeOH/H20 mixture (50/50; v/v). 5.3 g of NaCN dissolved in 20 ml of water are added dropwise. After stirring for 48 hours, the precipitate formed is filtered, rinsed with water and dried to give 27 g of the expected product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06294537B1 |
| 출처 데이터셋 | uspto-grants-2001_09 |
| ORD ID | ord-c96c12078ae548d29d26a151cbb5c173 |
| 출처 메모 | uspto-grants-2001_09 |