4-Quinolinecarboxaldehyde → 1-(Quinolin-4-yl)ethanol

HRID 1597363노트

반응식

HRID 1597363 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]=[O:12])=[CH:3][CH:2]=1.[Li][CH3:14]>CCOCC>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]([OH:12])[CH3:14])=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 780724-QuinolinecarboxaldehydeHCID 178418348HCID 178418348, 화합물

생성물 1

HCID 53147551-(Quinolin-4-yl)ethanol수율 64.9%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To 4-quinolinecarbaldehyde (2 g, 12.73 mmol) in 20 ml anhydrous ether, MeLi (1.4M, 10 ml, 13.9 mmol) was added dropwise over a period of five minutes at 0° C. The reaction mixture was stirred at room temperature tor 3 hours. The solution was partitioned between ether (20 ml) and water (10 ml). The organic layer was dried over sodium sulfate, filtered and concentrated to give 1.43 g (59%) of the product which was then used as such for the subsequent step.

후처리

  1. customThe solution was partitioned between ether (20 ml) and water (10 ml)
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-6eb32150d70c41e5ad6cbef956406831
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06294566B1

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