Ethyl bromoacetate → 1-{3-[(4'-Fluoro[1,1'-biphenyl]-4-yl)sulfonyl]-2-hydroxypropyl}-4,4-dimethyl-2,6-piperidinedione

HRID 1597425

반응식

HRID 1597425 반응식
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH3:18][C:19]1([CH3:27])[CH2:25][C:24](=[O:26])[NH:23][C:21](=[O:22])[CH2:20]1.Br[CH2:29][C:30](OCC)=[O:31]>>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:8]2[CH:7]=[CH:6][C:5]([S:2]([CH2:1][CH:30]([OH:31])[CH2:29][N:23]3[C:24](=[O:26])[CH2:25][C:19]([CH3:27])([CH3:18])[CH2:20][C:21]3=[O:22])(=[O:4])=[O:3])=[CH:10][CH:9]=2)=[CH:12][CH:13]=1

참가 물질

4

반응물 3

HCID 7748Ethyl bromoacetateHCID 142924,4-Dimethylpiperidine-2,6-dioneHCID 160868644-(4'-Fluorophenyl)-phenyl methyl sulfone

생성물 1

HCID 217000651-{3-[(4'-Fluoro[1,1'-biphenyl]-4-yl)sulfonyl]-2-hydroxypropyl}-4,4-dimethyl-2,6-piperidinedione

실험 절차

Reaction of 4-(4′-fluorophenyl)-phenyl methyl sulfone with ethyl 3,3-dimethylglutarimideacetate (prepared from 3,3-Dimethylglutarimide and ethyl bromoacetate (as in Example 120A) following the procedures of Example 126A, followed by reduction as described in Example 126B afforded the two title products which were chromatographically separated to give the desired products.

후처리

  1. customafforded the two title products which
  2. customwere chromatographically separated

출처 및 근거

ORD 기록
ord-143eb7e78acf4da381a50e842631a733
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06294573B1

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