Hydrazine → 5-(2-Furyl)-3-methyl-1H-pyrazole

HRID 1597454

반응식

HRID 1597454 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=O)[CH2:7][C:8](=O)[CH3:9].[NH2:12][NH2:13]>CO>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:7]=[C:8]([CH3:9])[NH:13][N:12]=1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 121681,3-Butanedione, 1-(2-furanyl)-

생성물 1

HCID 7001245-(2-Furyl)-3-methyl-1H-pyrazole수율 98%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 1.07 g (7.03 mmol) of 1-(2-furyl)-1,3-butanedione in 26 mL of MeOH at 25° C. was added 0.442 mL (14.07 mmol) of hydrazine. The reaction was stirred for 24 h then concentrated in vacuo. The residue was purified by silica gel flash column chromatography using hexanes/EtOAc (1:1) as eluent to give 1.02 g (98%) of title compound: low resolution MS (Cl) m/e 149 (MH+).

후처리

  1. concentrationthen concentrated in vacuo
  2. customThe residue was purified by silica gel flash column chromatography

출처 및 근거

ORD 기록
ord-6445a82a5e6e40e2a7db22ecbedcaaa5
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06294580B1

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