참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | Benzyl Chloride | HCID 7503 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 18-Crown-6 | HCID 28557 | — |
| 반응물 | Esculin | HCID 5281417 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 7-benzyloxy-6-D-glucosyloxycoumarin | HCID 22884042 | 86.4% |
반응 단계
Esculin [VIII] (1.0 g), benzyl chloride (1.0 g), potassium carbonate (0.7 g), a catalytic amount of 18-crown-6-ether and potassium iodide, and dimethylformamide (40 ml) were added to an eggplant-shaped flask (100 ml). The mixture was stirred at 60° C. for 8 hours to cause a reaction. The reaction mixture was concentrated under reduced pressure and the residue was poured into ice water. The precipitated crystals were filtered out and recrystallized from methanol to obtain 7-benzyloxy-6-D-glucosyloxycoumarin (VII-1) (melting point=184° to 186° C, mass spectrum (M+)=430, yield =86.4%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05736522 |
|---|
| 출처 데이터셋 | uspto-grants-1998_04 |
|---|
| ORD ID | ord-98904fd5cb18417d95f30b25c2f04850 |
|---|
| 출처 메모 | uspto-grants-1998_04 |
|---|
