3-(2-Morpholino-2-oxoethoxy)benzaldehyde → HCID 178437847, 화합물

HRID 1597883노트

반응식

HRID 1597883 반응식
[CH:1]1([N:6]2[C:10]([NH2:11])=[C:9]([C:12]([NH2:14])=[O:13])[C:8]([CH2:15][CH3:16])=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[N:17]1([C:23]([CH2:25][O:26][C:27]2[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=2)[CH:30]=O)=[O:24])[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>>[CH:1]1([N:6]2[C:10]3=[N:11][C:30]([C:29]4[CH:32]=[CH:33][CH:34]=[C:27]([O:26][CH2:25][C:23]([N:17]5[CH2:22][CH2:21][O:20][CH2:19][CH2:18]5)=[O:24])[CH:28]=4)=[N:14][C:12](=[O:13])[C:9]3=[C:8]([CH2:15][CH3:16])[NH:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

3

반응물 2

HCID 164955713-(2-Morpholino-2-oxoethoxy)benzaldehydeHCID 224493525-amino-1-cyclopentyl-3-ethyl-1H-pyrazole-4-carboxamide

생성물 1

HCID 178437847HCID 178437847, 화합물

반응 조건

온도
160 °C

실험 절차

A mixture of 1-cyclopentyl-3-ethyl-5-amino-1H-pyrazole-4-carboxamide (1.87 g), 3-[4-morpholinylcarbonylmethoxy]benzaldehyde (2.1 g, 8.43 mmol) and xylenes (20 ml) was heated at 160° C. for about 2 days. The solvent was removed, then methanol was added to the residue and the product was collected by filtration. Additional product was obtained from the filtrates and the product fractions were pooled and recrystallized from CH3CN/CHCl3 to afford 1-cyclopentyl-3-ethyl-6-[3-(4-morpholinylcarbonylmethoxy)-phenyl]pyrazolo[3,4-d]pyrimidin-4-one, m.p. 212°-213° C.

후처리

  1. customThe solvent was removed
  2. additionmethanol was added to the residue
  3. filtrationthe product was collected by filtration
  4. customAdditional product was obtained from the filtrates
  5. customrecrystallized from CH3CN/CHCl3

출처 및 근거

ORD 기록
ord-6d3ab7f12c814a2e9c7db9d23456a20e
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05736548

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