Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 6,7-Dimethoxy-4-(7-methyl-2,3-dihydro-indol-1-yl)-quinazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| 반응물 | 7-Methyl-2,3-dihydro-1H-indole | HCID 12377788 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 6,7-Dimethoxy-4-(7-methyl-2,3-dihydro-indol-1-yl)-quinazoline | HCID 18932710 | 65% |
반응 단계
Utilizing a procedure analogous to that described in Example 24, this product was prepared in 65% yield from 7-methyl-indoline (1 eq.), pyridine (2 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in DMF. (M.P. 146°-147° C.; GC-MS: 321 (M+); anal. RP18-HPLC RT: 4.41 min.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05736534 |
| 출처 데이터셋 | uspto-grants-1998_04 |
| ORD ID | ord-78a4400eaeac4389a2b7ba93a4e691a7 |
| 출처 메모 | uspto-grants-1998_04 |