Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloro-6,7-dimethoxyquinazoline → 4-(5-Benzyloxy-2,3-dihydro-indol-1-yl)-6,7-dimethoxy-quinazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| 반응물 | 5-(Benzyloxy)-2,3-dihydro-1H-indole | HCID 16794881 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 4-(5-Benzyloxy-2,3-dihydro-indol-1-yl)-6,7-dimethoxy-quinazoline | HCID 18932804 | 90% |
반응 단계
Utilizing a procedure analogous to that described in Example 1, this product was prepared in 90% yield from 5-benzyloxy-indoline (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 181°-182° C.; LC-MS: 415 (MH+); anal. RP18-HPLC RT: 4.78 min.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05736534 |
| 출처 데이터셋 | uspto-grants-1998_04 |
| ORD ID | ord-77f357c54e9f4f5b80e3122c26e25c34 |
| 출처 메모 | uspto-grants-1998_04 |