4-Chloro-6,7-dimethoxyquinazoline → HCID 18932853, 화합물

반응식

[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][NH:7]2.Cl[C:13]1[C:22]2[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=2)[N:16]=[CH:15][N:14]=1>>[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][N:7]2[C:13]1[C:22]2[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=2)[N:16]=[CH:15][N:14]=1

참가 물질

반응물 2

HCID 27693644-Chloro-6,7-dimethoxyquinazoline

HCID 138650465-Bromo-1,2,3,4-tetrahydroquinoline

생성물 1

HCID 18932853HCID 18932853, 화합물수율 4%

실험 절차

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 4% yield from 5-bromo-1,2,3,4-tetrahydroquinoline and 4-chloro-6,7-dimethoxy-quinazoline. (film; LC-MS: 399 (MH+)).

출처 및 근거

ORD 기록: ord-a22a5bcdbaad40ce9ade6de8b493bed0
출처 데이터셋: uspto-grants-1998_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05736534

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