참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Amino-3,5-dibromopyrazine | HCID 620004 | — |
| 반응물 | 6-(Aminomethyl)quinoline | HCID 1514384 | — |
| 용매 | Dichloromethane ethanol | HCID 21584144 | — |
| 생성물 | 6-bromo-N2-(quinolin-6-ylmethyl)pyrazine-2,3-diamine | HCID 45789418 | 49% |
반응 단계
A mixture of quinolin-6-ylmethanamine (13 g, 82 mmol), 3,5-dibromopyrazin-2-amine (21 g, 82 mmol) and di-isopropylethylamine (16 mL, 89 mmol) was heated to 130° C. for five hours. The reaction was diluted with dichloromethane:ethanol (9:1) and the resulting suspension was filtered. The precipitate was washed sequentially with water and ether and air dried to afford 6-bromo-N2-(quinolin-6-ylmethyl)pyrazine-2,3-diamine (13 g, 49%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07732604B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-703ad39523e24c928d2fda038c7b0137 |
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| 출처 메모 | uspto-grants-2010_06 |
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