Acetaldehyde → HCID 18929411, 화합물

HRID 1598504노트

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HRID 1598504 반응식
C([Li])CCC.Br[C:7]1[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=1[Cl:18].[CH:19](=[O:21])[CH3:20]>CCOCC>[Cl:18][C:8]1[CH:9]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:11]=[C:12]([Cl:13])[C:7]=1[CH:19]([OH:21])[CH3:20]

참가 물질

5

반응물 3

HCID 177AcetaldehydeHCID 12682564-Bromo-3,5-dichlorobenzotrifluorideHCID 178418339Butyllithium

생성물 1

HCID 18929411HCID 18929411, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매3회

실험 절차

To a mixture of 65.2 ml of n-butyllithium (1.61M in hexane) and 100 ml of anhydrous ether was added dropwise 29.3 g of 4-bromo-3,5-dichlorobenzotrifluoride (3) in 30 ml of anhydrous ether at -78° C., followed by stirring for 20 minutes. Subsequently, 6.2 ml of acetaldehyde in 50 ml of anhydrous ether was added dropwise to the mixture at the same temperature, followed by stirring at 0° C. Ice waster was added to the reaction mixture, followed by extraction with ether, drying over anhydrous magnesium sulfate and concentration under reduced pressure to give 23.5 g of the desired product in the form of a colorless oil (crude yield 90.7% ).

후처리

  1. stirringby stirring at 0° C
  2. additionIce waster was added to the reaction mixture
  3. extractionfollowed by extraction with ether
  4. dry with materialdrying over anhydrous magnesium sulfate and concentration under reduced pressure

출처 및 근거

ORD 기록
ord-19fa225dfb0f4dbd96abb58ca7f5d241
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05739083

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