Tetrahydrofuran → N-propyl-2,3-dihydro-1H-inden-2-amine

HRID 1598564노트

반응식

HRID 1598564 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].C([CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]1N)(=O)CC.[Cl-].[NH4+:22].O1C[CH2:26][CH2:25][CH2:24]1>>[CH2:24]([NH:22][CH:11]1[CH2:12][C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:19]1)[CH2:25][CH3:26]

참가 물질

5

반응물 4

HCID 8028Tetrahydrofuran2회HCID 25517Ammonium ChlorideHCID 21226445Aluminium lithium hydride2회HCID 543218082-Propionyl aminoindane

생성물 1

HCID 17221237N-propyl-2,3-dihydro-1H-inden-2-amine

실험 절차

In 100 ml of tetrahydrofuran was suspended 5.7 g of lithium aluminum hydride, and to the suspension was added dropwise 18.9 g of 2-propionyl aminoindane dissolved in 150 ml of tetrahydrofuran. The mixture was refluxed under heating for 2 hours. After cooling, excessive lithium aluminum hydride was treated with a saturated ammonium chloride aqueous solution, and insolubles were removed by filtration. The filtrate was condensed, and chloroform was added to the residue. After the mixture was washed with 10 water and dried, the solvent was removed to obtain 17.5 g of 2-propylaminoindane.

후처리

  1. temperatureThe mixture was refluxed
  2. temperatureunder heating for 2 hours
  3. temperatureAfter cooling
  4. customwere removed by filtration
  5. customcondensed, and chloroform
  6. additionwas added to the residue
  7. washAfter the mixture was washed with 10 water
  8. customdried
  9. customthe solvent was removed

출처 및 근거

ORD 기록
ord-968c44bf8df84e558d1424ad845337e4
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05739132

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