참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-Butanesulfonyl chloride | HCID 75430 | — |
| 반응물 | 2-amino-5-[pyridazin-3(2H)-on-6-yl]indane | HCID 18929773 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-n-butylsulfonylamino-5-[pyridazin-3(2H)-on-6-yl]indane | HCID 18929802 | 72.9% |
반응 단계
In 50 ml of dimethylformamide were dissolved 1.14 g of 2-amino-5-[pyridazin-3(2H)-on-6-yl]indane and 0.8 g of triethyl amine, and 1.25 g of n-butanesulfonyl chloride was added thereto. The mixture was stirred at 50° C for 30 minutes and then stirred at room temperature overnight. The solvent was removed, water was added to the residue, and crystals precipitated were collected by filtration. The resulting crystals were recrystallized from methanol to obtain 1.27 g of 2-n-butylsulfonylamino-5-[pyridazin-3(2H)-on-6-yl]indane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05739132 |
|---|
| 출처 데이터셋 | uspto-grants-1998_04 |
|---|
| ORD ID | ord-5af222c59385436a96b3c24993006ea6 |
|---|
| 출처 메모 | uspto-grants-1998_04 |
|---|
