Sulfuric Acid → 4-Chloro-2-fluoro-5-sulfamoylbenzoic acid

HRID 1599102노트

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](Cl)(Cl)Cl)=[C:4]([F:12])[CH:3]=1.[OH:13][S:14](Cl)(=O)=[O:15].S(=O)(=O)(O)[OH:19].[OH-:23].[NH4+:24]>>[Cl:1][C:2]1[C:7]([S:14](=[O:15])(=[O:13])[NH2:24])=[CH:6][C:5]([C:8]([OH:19])=[O:23])=[C:4]([F:12])[CH:3]=1

참가 물질

반응물 4

HCID 1118Sulfuric Acid

HCID 14923Ammonium Hydroxide

HCID 24638Chlorosulfonic acid

HCID 189316154-Chloro-2-fluoro-1-(trichloromethyl)benzene

생성물 1

HCID 124625724-Chloro-2-fluoro-5-sulfamoylbenzoic acid

실험 절차

4-chloro-2-fluoro-benzotrichloride (III) obtained in step (A) is chlorosulfonylated by treatment with sulfuric chlorohydrin in the presence of sulfuric acid and the resulting product is ammonolyzed by treatment with ammonium hydroxide to give 4-chloro-2-fluoro-5-sulfamoyl-benzoic acid (IV);

출처 및 근거

ORD 기록: ord-0e15f147aa2947928872a1644447127e
출처 데이터셋: uspto-grants-1998_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05739361

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