2-Chlor-5-nitro-benzolsulfonylfluorid → 5-Amino-2-chlorobenzene-1-sulfonyl fluoride

HRID 1599206노트

반응식

HRID 1599206 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[S:11]([F:14])(=[O:13])=[O:12]>C(O)(=O)C.[Fe]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[S:11]([F:14])(=[O:12])=[O:13]

참가 물질

4

반응물 1

HCID 543404312-Chlor-5-nitro-benzolsulfonylfluorid

생성물 1

HCID 542778915-Amino-2-chlorobenzene-1-sulfonyl fluoride

시약·촉매·용매 2

HCID 23925Iron촉매HCID 176Acetic Acid용매

실험 절차

The 2-chloro-5-nitro benzene sulphonylfluoride (2.4 parts) was stirred. in glacial acetic acid (25 parts) with iron powder (2 parts). Heated to reflux and stirred at reflux for 2.5 hours, then cooled to room temperature, poured onto ice/water and allowed to stand at room temperature overnight. The resultant precipitate was filtered off and dried in air to yield the product 2-chloro-5-amino benzene sulphonylfluoride (0.8 parts).

후처리

  1. temperatureHeated
  2. temperatureto reflux
  3. temperatureat reflux for 2.5 hours
  4. additionpoured onto ice/water
  5. filtrationThe resultant precipitate was filtered off
  6. customdried in air

출처 및 근거

ORD 기록
ord-d61bdd17c2804f5a80fda73eca223505
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05739299

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