Acetic Acid → HCID 10838316, 화합물

HRID 1599241노트

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HRID 1599241 반응식
[CH3:1][N:2]1[C:6]2=[N:7][C:8]([S:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:9][CH:10]=[C:5]2[N:4]=[C:3]1[CH2:18][O:19][C:20]1[CH:52]=[CH:51][C:23]([CH2:24][CH:25]2[S:29][C:28](=[O:30])[N:27](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[C:26]2=[O:50])=[CH:22][CH:21]=1.C(O)(=O)C>O>[CH3:1][N:2]1[C:6]2=[N:7][C:8]([S:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)=[CH:9][CH:10]=[C:5]2[N:4]=[C:3]1[CH2:18][O:19][C:20]1[CH:52]=[CH:51][C:23]([CH2:24][CH:25]2[S:29][C:28](=[O:30])[NH:27][C:26]2=[O:50])=[CH:22][CH:21]=1

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 10723563HCID 10723563, 화합물

생성물 1

HCID 10838316HCID 10838316, 화합물수율 97.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A procedure similar to that described in Example 12 was repeated, except that 1.58 g of 5-[4-(3-methyl-5-phenylthioimidazo[5,4-b]pyridin-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione (prepared as described in Preparation 91) were treated with 20 ml of a 3:1 by volume mixture of acetic acid and water. After working up the product as described in Example 12, the resulting crude product was crystallized by trituration with ethyl acetate, to give 1.02 g of the title compound, melting at 166°-168° C.

후처리

  1. customthe resulting crude product was crystallized by trituration with ethyl acetate

출처 및 근거

ORD 기록
ord-cfe31739dba2428ca664b23f2379f121
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05739345

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