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Ethanol → 5-{4-[2-(3-Methylimidazo[5,4-b]pyridin-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione

HRID 1599246
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HRID 1599246 반응식
[NH2:1][C:2]1[C:3]([NH:8][CH3:9])=[N:4][CH:5]=[CH:6][CH:7]=1.O=[CH:11][CH2:12][CH2:13][O:14][C:15]1[CH:28]=[CH:27][C:18]([CH2:19][CH:20]2[S:24][C:23](=[O:25])[NH:22][C:21]2=[O:26])=[CH:17][CH:16]=1.C(O)C.II>COCCOC.C(O)(=O)C>[CH3:9][N:8]1[C:3]2=[N:4][CH:5]=[CH:6][CH:7]=[C:2]2[N:1]=[C:11]1[CH2:12][CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([CH2:19][CH:20]2[S:24][C:23](=[O:25])[NH:22][C:21]2=[O:26])=[CH:27][CH:28]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 702EthanolHCID 807IodineHCID 104929285-[4-(3-Oxopropoxy)benzyl]thiazolidine-2,4-dioneHCID 123436692-N-methylpyridine-2,3-diamine

생성물 1

HCID 105719565-{4-[2-(3-Methylimidazo[5,4-b]pyridin-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione수율 3%

시약·촉매·용매 2

HCID 176
Acetic Acid
용매
HCID 80711,2-Dimethoxyethane용매

실험 절차

A procedure similar to that described in Example 18 was repeated, except that 0.94 g of 3-amino-2-methylaminopyridine (prepared as described in Preparation 105), 2.10 g of 5-[4-(3-oxopropoxy)benzyl]thiazolidine-2,4-dione (prepared as described in Preparation 107), 6 ml of ethanol, 3 ml of acetic acid, 2.32 g of iodine and 30 ml of 1,2-dimethoxyethane were used. After working up the product as described in Example 18, the resulting crude product was purified by column chromatography through silica gel, using ethyl acetate as the eluent, to give 85 mg of the title compound, melting at 96°-100° C.

후처리

  1. customthe resulting crude product was purified by column chromatography through silica gel

출처 및 근거

ORD 기록
ord-8048fad891f144fbbbae9b7d8b84a250
출처 데이터셋
uspto-grants-1998_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05739345

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