1,1'-Carbonyldiimidazole → HCID 15224969, 화합물

HRID 1599408노트

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HRID 1599408 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[N:12]1[C:16]([CH3:17])=[C:15]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[N:14]=[CH:13]1.[C:23](N1C=CN=C1)(N1C=CN=C1)=[O:24]>ClC1C=CC=CC=1Cl>[CH2:21]([O:20][C:18]([C:15]1[N:14]=[C:13]2[C:23](=[O:24])[NH:1][C:2]3[C:3](=[CH:4][CH:5]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:7]=3)[N:12]2[C:16]=1[CH3:17])=[O:19])[CH3:22]

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 23295839HCID 23295839, 화합물

생성물 1

HCID 15224969HCID 15224969, 화합물수율 77%

시약·촉매·용매 1

HCID 72391,2-Dichlorobenzene용매

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온도
180 °C

실험 절차

A mixture of 1-(2-amino-4-trifluoromethylphenyl)-4-ethoxycarbonyl-5-methyl-1H-imidazole (12.3 g, 39.3 mmol), 1,1'-carbonyldiimidazole (7.0 g, 43.2 mmol) in 1,2-dichlorobenzene (250 ml) was stirred at 180° C. for 6 h under N2. The reaction mixture was cooled to room temperature. The precipitate was filtered off and washed with acetone to give 10.2 g (77%) of the title compound. M.p. >250° C.

후처리

  1. temperatureThe reaction mixture was cooled to room temperature
  2. filtrationThe precipitate was filtered off
  3. washwashed with acetone

출처 및 근거

ORD 기록
ord-8b84273c35244c68a5fe394760f18d2d
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05741785

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