HCID 53754201, 화합물 → Ethyl 6-amino-1H-benzimidazole-2-acetate

HRID 1599468노트

반응식

HRID 1599468 반응식
[N+:1]([C:4]1[CH:18]=[CH:17][C:7]2[N:8]=[C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:10][C:6]=2[CH:5]=1)([O-])=O>[Pd].C(O)C>[NH2:1][C:4]1[CH:18]=[CH:17][C:7]2[N:8]=[C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:10][C:6]=2[CH:5]=1

참가 물질

4

반응물 1

HCID 53754201HCID 53754201, 화합물

생성물 1

HCID 54171359Ethyl 6-amino-1H-benzimidazole-2-acetate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of ethyl 5-nitrobenzimidazole-2-acetate (206 mg, 0.83 mmol, 1 equiv.), 10% palladium on carbon (88 mg, 0.08 mmol, 0.1 equiv.), and absolute ethanol (8 mL) was stirred at room temperature under hydrogen (balloon). After 45 minutes, the reaction was filtered through Celite®, and the filtrate was concentrated to afford crude ethyl 5-aminobenzimidazole-2-acetate. This was used without further purification.

후처리

  1. filtrationthe reaction was filtered through Celite®
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-943e802d0a5a4a16a2ed835d1e0a965d
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05741804

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