Trifluoroacetic acid → 4-[2-(Pyrimidin-2-ylamino)ethyloxy]benzoyl-2(S)-benzyloxycarbonyl-amino-beta-alanine

HRID 1599945노트

반응식

HRID 1599945 반응식
C([O:5][C:6](=[O:39])[C@H:7]([C:29]([O:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:30])[CH2:8][N:9]([C:11](=[O:28])[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]2[N:27]=[CH:26][CH:25]=[CH:24][N:23]=2)=[CH:14][CH:13]=1)[NH2:10])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:23]1[CH:24]=[CH:25][CH:26]=[N:27][C:22]=1[NH:21][CH2:20][CH2:19][O:18][C:15]1[CH:14]=[CH:13][C:12]([C:11]([N:9]([NH2:10])[CH2:8][C@H:7]([C:29]([O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[O:30])[C:6]([OH:39])=[O:5])=[O:28])=[CH:17][CH:16]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86752454HCID 86752454, 화합물

생성물 1

HCID 867524534-[2-(Pyrimidin-2-ylamino)ethyloxy]benzoyl-2(S)-benzyloxycarbonyl-amino-beta-alanine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 25-1 (840 mg, 1.6 mmol) and CH2Cl2 (10 ml) at ambient temperature was treated with TFA (10 ml). After stirring for 4.0 h, the reaction mixture was concentrated and the residual TFA removed azeotropically with toluene. Trituration of the resulting waxy solid with ether provided 25-2 as a white solid.

후처리

  1. concentrationthe reaction mixture was concentrated
  2. customthe residual TFA removed azeotropically with toluene

출처 및 근거

ORD 기록
ord-8eba998bfd2a4f74b3f8c534a5c325ed
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05741796

반응 노트

불러오는 중…