Sulfuric Acid → 4-Chloro-3-(2,4-dichloro-5-formylphenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole

HRID 1599986노트

반응식

HRID 1599986 반응식
Br[CH:2](Br)[C:3]1[C:4]([Cl:21])=[CH:5][C:6]([Cl:20])=[C:7]([C:9]2[C:13]([Cl:14])=[C:12]([O:15][CH:16]([F:18])[F:17])[N:11]([CH3:19])[N:10]=2)[CH:8]=1.S(=O)(=O)(O)[OH:24]>>[Cl:14][C:13]1[C:9]([C:7]2[CH:8]=[C:3]([CH:2]=[O:24])[C:4]([Cl:21])=[CH:5][C:6]=2[Cl:20])=[N:10][N:11]([CH3:19])[C:12]=1[O:15][CH:16]([F:18])[F:17]

참가 물질

3

반응물 2

HCID 1118Sulfuric AcidHCID 150305713-(5-dibromomethyl-2,4-dichlorophenyl)-4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazole

생성물 1

HCID 156721724-Chloro-3-(2,4-dichloro-5-formylphenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole

실험 절차

Analogously to Example 12, 45.5 g (91 mmol) of 3-(5-dibromomethyl-2,4-dichlorophenyl)-4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazole were introduced into 65 ml of concentrated sulfuric acid. After working up, 20 g of the product were obtained. 1H-NMR (270 MHz, in CDCl3): δ [ppm]=10.41 (s,1H), 8.02 (s,1H), 7.65 (s,1H),6.77 (t,1H), 3.87 (s,3H).

출처 및 근거

ORD 기록
ord-4909bd7533c2424fb554fd5e0a9ce4f4
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05744426

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