Imidazole → HCID 18926613, 화합물

HRID 1600165노트

반응식

HRID 1600165 반응식
[CH3:1][N:2]([CH3:16])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([N+:13]([O-:15])=[O:14])[CH:11]=2)[NH:6][CH:5]=1.[NH:17]1C=CN=[CH:18]1>C1(C)C(C)=CC=CC=1>[N:2]1([CH2:3][C:4]2[C:12]3[C:7](=[CH:8][CH:9]=[C:10]([N+:13]([O-:15])=[O:14])[CH:11]=3)[NH:6][CH:5]=2)[CH:16]=[CH:18][N:17]=[CH:1]1

참가 물질

4

반응물 2

HCID 795ImidazoleHCID 18882Indole, 3-((dimethylamino)methyl)-5-nitro-

생성물 1

HCID 18926613HCID 18926613, 화합물수율 93.5%

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

A mixture of N,N-dimethyl-5-nitro-1H-indole-3-methanamine (J.Med, Chem, 9, 140,(1966)) (9.10 g) and imidazole (2.96 g) in xylene (120 ml) was heated under reflux for 2.5 hours and then cooled. The solid was filtered off, washed with ether and dried to give the title compound (9.40 g), m.p. 230°-232° C. (from ethyl acetate/methanol). Found: C,59.85; H,4.39; N,22.80. C12H10N4O2 requires: C,59.50; H,4.16; N,23.13%.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 2.5 hours
  3. temperaturecooled
  4. filtrationThe solid was filtered off
  5. washwashed with ether
  6. customdried

출처 및 근거

ORD 기록
ord-dab7a92d21104d1abe9121c894b2b43a
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05744488

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