Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 16004생성일: 2026년 10월 23일
2-(Dimethylamino)ethanol → N,N-dimethyl-2-{[1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]oxy}ethanamine
https://huagongshe.com/ko/reaction/16004
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-(Dimethylamino)ethanol | HCID 7902 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 6-((6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)quinoline | HCID 54775608 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 생성물 | N,N-dimethyl-2-{[1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]oxy}ethanamine | HCID 59341930 | 74% |
반응 단계
A mixture of 6-((6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)quinoline, (100, 0.293), triethylamine (123 μL, 0.879 mmol), N,N-dimethylethanolamine (959 μL, 0.586 mmol) in n-butanol (3.0 mL) was heated in the microwave at 120° C. for 20 minutes, then concentrated. The crude product was purified by flash chromatography using a Horizon purification system on a 25S column eluting with chloroform/7 N ammonia in methanol (0.1-5%) to afford the title compound (75 mg, 74%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07732604B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
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| ORD ID | ord-7e8a06e8dd3a4228b8636c042c325e3e |
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| 출처 메모 | uspto-grants-2010_06 |
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