Triethylamine → HCID 178512421, 화합물
반응식
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH:15]3[CH2:20][CH2:19][CH:18](N)[CH2:17][CH2:16]3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CS[C:24](=[N:36][C:37]([O:39][CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)=[O:38])[NH:25][C:26]([O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:27].C([N:49](CC)CC)C>CN(C)C=O>[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][CH2:14][CH:15]3[CH2:16][CH2:17][CH:18]([N:25]([C:26]([O:28][CH2:29][C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)=[O:27])[C:24]([NH:36][C:37]([O:39][CH2:40][C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=4)=[O:38])=[NH:49])[CH2:19][CH2:20]3)[CH2:11][CH2:12]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1참가 물질
5
실험 절차
A solution of trans-N-{4-[2-(4-phenyl-piperazin-1-yl)-ethyl]-cylohexylamine (0.43 g, 1.5 mmol), S-methyl-N,N'-dicarbobenzyloxy isothiourea (Nowak K. and Kania L., Rocz. Chem., 1969;43(11):1953-1960) (0.59 g, 1.65 mmol) and triethylamine (0.18 g, 1.8 mmol) in dimethylformamide (DMF) (50 mL) was stirred at room temperature 3 days. An additional amount of the starting amine (0.075 g, 0.26 mmol) was added, and the reaction mixture was allowed to stand one more day and then evaporated to dryness. The residue was recrystallized from Et2O-hexane to yield trans-N-{4-[2-(4-phenyl-piperazin-1-yl)-ethyl]-cyclohexyl-N, N'-dicarbobenzyloxyguanidine 0.568 g (63%) white solid; mp 136-137° C.