Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formamide → Tert-butyl 4-(2-carbamoylbenzofuran-5-yl)piperazine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formamide | HCID 713 | — |
| 반응물 | 1-Piperazinecarboxylic acid, 4-[2-(ethoxycarbonyl)-5-benzofuranyl]-, 1,1-dimethylethyl ester | HCID 11176275 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | Tert-butyl 4-(2-carbamoylbenzofuran-5-yl)piperazine-1-carboxylate | HCID 11244883 | — |
반응 단계
A solution of 3 g of ethyl 5-(4-tert-butoxycarbonyl-1-piperazinyl)benzofuran-2-carboxylate in 100 ml of N-methylpyrrolidone is stirred for 5 hours with 1 g of formamide and 3 g of sodium alkoxide. After customary working up, 5-(4-tert-butoxycarbonyl-1-piperazinyl)benzofuran-2-carboxamide, m.p. 198-200°, is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05977112 |
| 출처 데이터셋 | uspto-grants-1999_11 |
| ORD ID | ord-13f3e0e44c3c4141a37655c9981121d3 |
| 출처 메모 | uspto-grants-1999_11 |