Water → Ethyl 2-pyridin-3-ylpropanoate
반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:2]=1.[Li+].[CH3:14]C([N-]C(C)C)C.O.CCOCC>C1COCC1>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]([CH3:14])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:2]=1참가 물질
6
실험 절차
Ethyl 3-pyridylacetate (12.2 g, 73.9 mmol) in THF (30 ml) was added to LDA (81 mmol) in THF (150 ml) over 10 min at -78° C. After 1 h Mel (5.1 ml, 81 mmol) was added to the yellow suspension and the mixture brought to room temperature. H2O (300 ml) and ether (300 ml) was added, the mixture separated, and the organic layer washed with H2O and brine, dried and evaporated to give ethyl 2-(3-pyridyl)propanoate (8.3 g) as a yellow oil.
후처리
- additionAfter 1 h Mel (5.1 ml, 81 mmol) was added to the yellow suspension
- custombrought to room temperature
- customthe mixture separated
- washthe organic layer washed with H2O and brine
- customdried
- customevaporated
출처 및 근거
- ORD 기록
- ord-e1e67158406e495f8ce377dc45162e4c
- 출처 데이터셋
- uspto-grants-1999_11
- 특허 번호
- US05977116
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