6-Chloro-1H-pyrrolo[2,3-b]pyridine → 1-(Chloro-1H-pyrrolo[2.3-b]pyridin-3-yl)-2-dimethylamino-ethanone

HRID 1600881노트

반응식

HRID 1600881 반응식
Cl[C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[CH:10][C:5]2=[CH:4][CH:3]=1.[ClH:11].[CH3:12][N:13]([CH2:15][C:16](Cl)=[O:17])[CH3:14]>>[Cl:11][N:8]1[C:6]2=[N:7][CH:2]=[CH:3][CH:4]=[C:5]2[C:10]([C:16](=[O:17])[CH2:15][N:13]([CH3:14])[CH3:12])=[CH:9]1

참가 물질

3

반응물 2

HCID 113441186-Chloro-1H-pyrrolo[2,3-b]pyridineHCID 139949912-(Dimethylamino)acetyl chloride hydrochloride

생성물 1

HCID 867547391-(Chloro-1H-pyrrolo[2.3-b]pyridin-3-yl)-2-dimethylamino-ethanone

실험 절차

The title compound was prepared from 6-chloro-1H-pyrrolo[2,3-b]pyridine (Synthesis, 992, 7, 661-663) and dimethylaminoacetyl chloride hydrochloride (Arch. Pharm. 991, 324, 433-437) in a procedure similar to Example 1. NMR (D6DMSO) δ8 12.65 (s, 1H), 8.60 (s, 1H), 7.95 (d, 1H), 7.32 (d, 1H), 3.60 (s, 2H), 2.22 (s, 3H). 13C NMR (D6DMSO) 195.6, 147.5, 144.4, 134.8, 132.7, 118.0, 116.8, 114.0, 65.9, 45,4 (2). Mass spectrum: 237,239 (P+1, P+3).

출처 및 근거

ORD 기록
ord-cbcb6c65257045258a726ca57f5cd560
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05977131

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