Sulfuric Acid → Methyl 3-(4-hydroxyphenyl)benzoate

HRID 1600944노트

반응식

HRID 1600944 반응식
[C:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1)([OH:3])=[O:2].S(=O)(=O)(O)O.[C:22](=O)([O-])O.[Na+]>CO>[CH3:22][O:2][C:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1)=[O:3]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 516892Sodium BicarbonateHCID 7224324'-Hydroxy-biphenyl-3-carboxylic acid

생성물 1

HCID 5097337Methyl 3-(4-hydroxyphenyl)benzoate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Solid 3'-carboxybiphenyl-4-ol (1.5 g) was suspended in methanol (10 ml) and concentrated sulfuric acid (1 ml). The mixture was heated at reflux for 16 hours. After cooling, the mixture was basified by the addition of solid sodium hydrogen carbonate. The white solid which formed was filtered and washed with copious amounts of water to give the sub-title compound as a white solid (1.5 g).

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 16 hours
  3. temperatureAfter cooling
  4. customThe white solid which formed
  5. filtrationwas filtered
  6. washwashed with copious amounts of water

출처 및 근거

ORD 기록
ord-dbef5c807bcf487797086022dff1f618
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05977105

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