Methyl 3-(4-hydroxyphenyl)benzoate → 4-(3-Hydroxymethylphenyl)phenol

HRID 1600945노트

반응식

HRID 1600945 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].C[O:8][C:9]([C:11]1[CH:12]=[C:13]([C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)[CH:14]=[CH:15][CH:16]=1)=O>O1CCCC1>[OH:8][CH2:9][C:11]1[CH:12]=[C:13]([C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)[CH:14]=[CH:15][CH:16]=1

참가 물질

4

반응물 2

HCID 5097337Methyl 3-(4-hydroxyphenyl)benzoateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 218306904-(3-Hydroxymethylphenyl)phenol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
0 °C

실험 절차

A solution of lithium aluminium hydride (1 M in ether, 2.5 ml) was added to dry tetrahydrofuran (10 ml) and the solution cooled to 0° C. A solution of 3'-methoxycarbonylbiphenyl-4-ol in (0.57 g) in tetrahydrofuran (10 ml) was then added and the resulting solution stirred at room temperature for 30 minutes. The reaction was then quenched by the addition of water (0.1 ml) followed by aqueous sodium hydroxide (50%, 0.1 ml) and then water (0.5 ml). The mixture was acidified with dilute aqueous hydrochloric acid (2 M) and extracted with ethyl acetate. The organic extract was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the sub-title compound as a white solid (0.48 g).

후처리

  1. customThe reaction was then quenched by the addition of water (0.1 ml)
  2. extractionextracted with ethyl acetate
  3. extractionThe organic extract
  4. dry with materialwas dried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4b184d30990c42269ec39029db9c71cc
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05977105

반응 노트

불러오는 중…