Boron tribromide → 4-(1,3-Thiazol-2-yl)phenol

HRID 1600956노트

반응식

HRID 1600956 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:10][CH:11]=[CH:12][N:13]=2)=[CH:5][CH:4]=1.B(Br)(Br)Br>ClCCl>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[S:10][CH:11]=[CH:12][N:13]=2)=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 112984492-(4-Methoxy-phenyl)-thiazole

생성물 1

HCID 2238404-(1,3-Thiazol-2-yl)phenol

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
-78 °C

실험 절차

Prepared according to the method described in Example 36b) from 2-(4-methoxyphenyl)thiazole (1.7 g), dichloromethane (20 ml) and boron tribromide (1.0 M in dichloromethane, 17.8 ml) with stirring at -78° C. After work up the residue was triturated with ether to give the sub-title compound a pale yellow solid (1.2 g).

후처리

  1. customPrepared
  2. customAfter work up the residue was triturated with ether

출처 및 근거

ORD 기록
ord-8619ce348643452fb449d8cd8f67af90
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05977105

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