Methylamine → N-Methyl 6-((2R)-2-hydroxy-4-(3-pyridyl)-1-butoxy)naphthalen-2-yloxyacetamide

HRID 1600965노트

반응식

HRID 1600965 반응식
C[O:2][C:3](=O)[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:16][CH2:17][C@H:18]([OH:27])[CH2:19][CH2:20][C:21]3[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=3)[CH:12]=2)[CH:7]=1.[CH3:29][NH2:30]>CO>[CH3:29][NH:30][C:3](=[O:2])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:16][CH2:17][C@H:18]([OH:27])[CH2:19][CH2:20][C:21]3[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=3)[CH:12]=2)[CH:7]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 541642626-((2R)-2-Hydroxy-4-(3-pyridyl)-1-butoxy)naphthalen-2-yloxyacetic acid methyl ester

생성물 1

HCID 54489683N-Methyl 6-((2R)-2-hydroxy-4-(3-pyridyl)-1-butoxy)naphthalen-2-yloxyacetamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 6-((2R)-2-hydroxy-4-(3-pyridyl)-1-butoxy)naphthalen-2-yloxyacetic acid methyl ester (0.215 g) in methanol (10 ml) was saturated with methylamine gas. After 16 hours the crystalline product was collected by filtration and dried under vacuum to give the title compound as a solid (0.10 g).

후처리

  1. filtrationAfter 16 hours the crystalline product was collected by filtration
  2. customdried under vacuum

출처 및 근거

ORD 기록
ord-4865a5ec60584353a5005cd9bbf9ff21
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05977105

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