홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Boron tribromide → HCID 69772095, 화합물

HRID 1601120
노트
인쇄 미리보기

반응식

HRID 1601120 반응식
C[O:2][C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:20]=[CH:19][C:18]([S:21]([NH:24][C@@H:25]([CH2:29][C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[C:26]([OH:28])=[O:27])(=[O:23])=[O:22])=[CH:17][CH:16]=3)[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.B(Br)(Br)[Br:37]>ClCCl.O>[BrH:37].[OH:2][C:3]1[CH:4]=[C:5]([N:9]2[CH2:10][CH2:11][N:12]([C:15]3[CH:16]=[CH:17][C:18]([S:21]([NH:24][C@@H:25]([CH2:29][C:30]4[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=4)[C:26]([OH:28])=[O:27])(=[O:22])=[O:23])=[CH:19][CH:20]=3)[CH2:13][CH2:14]2)[CH:6]=[CH:7][CH:8]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 25134Boron tribromideHCID 12114676HCID 12114676, 화합물

생성물 1

HCID 69772095HCID 69772095, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매2회

반응 조건

온도
-78 °C

실험 절차

To a stirred suspension of (S)-2-{4-[4-(3-methoxy-phenyl)-piperazin-1-yl]-benzenesulfonylamino}-3-phenyl-propionic acid (0.103 g, 0.000208 mol) in dichloromethane (2 mL) at -78° C. under nitrogen was added dropwise a 1.0 M solution of boron tribromide in dichloromethane (1.0 mL, 0.0010 mol). The mixture was stirred for 15 minutes at -78° C. and then allowed to warm to +3° C. After 6 hours, the reaction mixture was diluted with water. The resulting suspension was stirred overnight. The solids were filtered off, washed with additional water, and dried in vacuo to give the title compound as an off-white solid; yield 0.069 g (69%), mp=229-230° C.

후처리

  1. temperatureto warm to +3° C
  2. waitAfter 6 hours
  3. stirringThe resulting suspension was stirred overnight
  4. filtrationThe solids were filtered off
  5. washwashed with additional water
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-9401af9ce4634e4caae79c76b615b5af
출처 데이터셋
uspto-grants-1999_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05977141

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트