Triethylamine → N-(3-chloropropyl)-4-nitrobenzamide

HRID 1601338

반응식

HRID 1601338 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][NH2:5].C(N(CC)CC)C.[N+:13]([C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[CH:18][CH:17]=1)([O-:15])=[O:14]>C(Cl)Cl>[Cl:1][CH2:2][CH2:3][CH2:4][NH:5][C:20](=[O:21])[C:19]1[CH:18]=[CH:17][C:16]([N+:13]([O-:15])=[O:14])=[CH:24][CH:23]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 85024-Nitrobenzoyl chlorideHCID 846293-Chloropropylamine

생성물 1

HCID 3421653N-(3-chloropropyl)-4-nitrobenzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 6.43 g (49 mmol) 3-chloropropylamine and 13.6 ml (98 mmol) triethylamine in 220 ml methylene chloride was cooled by an ice bath and 9 g (48.5 mmol) 4-nitrobenzoyl chloride were added fractionwise. After one hour stirring at room temperature the organic phase was washed twice with water, dried over MgSO4 and concentrated in vacuo to afford 10.68 g (91%). of beige crystals. 1H NMR was consistent with the desired structure.

후처리

  1. washwas washed twice with water
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated in vacuo
  4. customto afford 10.68 g (91%)

출처 및 근거

ORD 기록
ord-f96156a5394c4311839ffe582a66b357
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05977179

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