Methyl 3-(chlorosulfonyl)propanoate → Methyl 3-[2-[2-(4-methylphenyl)ethoxy]ethylaminosulphonyl]propanoate

HRID 1601735노트

반응식

HRID 1601735 반응식
Cl.[CH3:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][O:11][CH2:12][CH2:13][NH2:14])=[CH:5][CH:4]=1.Cl[S:16]([CH2:19][CH2:20][C:21]([O:23][CH3:24])=[O:22])(=[O:18])=[O:17]>ClCCl>[CH3:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][O:11][CH2:12][CH2:13][NH:14][S:16]([CH2:19][CH2:20][C:21]([O:23][CH3:24])=[O:22])(=[O:18])=[O:17])=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 4962888Methyl 3-(chlorosulfonyl)propanoateHCID 187790752-[2-(4-Methylphenyl)ethoxy]ethanamine hydrochloride

생성물 1

HCID 18779034Methyl 3-[2-[2-(4-methylphenyl)ethoxy]ethylaminosulphonyl]propanoate수율 46.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The subtitle compound (2.49 g) was prepared according to the procedure in example 5 part d using 2-[2-(4-methylphenyl)ethoxy]ethanamine hydrochloride (3.5 g) triethylamine 4.74 ml) methyl 3-(chlorosulphonyl)propanoate (3.08 g), and dichloromethane (80 ml).

출처 및 근거

ORD 기록
ord-47f0e61b71a34350b72e0fe02de520a2
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05977384

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