Glycolic Acid → (5-ethoxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methanol

HRID 1601867노트

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HRID 1601867 반응식
[NH2:1][C:2]1[C:3]([NH:11][CH3:12])=[N:4][C:5]([O:8][CH2:9][CH3:10])=[CH:6][CH:7]=1.[C:13]([OH:17])(=O)[CH2:14]O>>[CH2:9]([O:8][C:5]1[N:4]=[C:3]2[N:11]([CH3:12])[C:14]([CH2:13][OH:17])=[N:1][C:2]2=[CH:7][CH:6]=1)[CH3:10]

참가 물질

3

반응물 2

HCID 757Glycolic AcidHCID 10583205HCID 10583205, 화합물

생성물 1

HCID 10560253(5-ethoxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methanol수율 62.2%

실험 절차

A procedure similar to that described in Preparation 43 was repeated, except that 4.15 g 3-amino-6-ethoxy-2-methylaminopyridine (prepared as described in Preparation 97), and 5.66 g of glycolic acid were used, and that the product was purified by column chromatography through silica gel, using a 10:1 by volume mixture of ethyl acetate and methanol as the eluent, to give 3.20 g of the title compound, melting at 161° C.

후처리

  1. customA procedure similar to that described in Preparation 43
  2. customthat the product was purified by column chromatography through silica gel
  3. additionby volume mixture of ethyl acetate and methanol as the eluent

출처 및 근거

ORD 기록
ord-cb4357bfdc60468683f4d6371c3214bb
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05977365

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