Cyclopropanecarbonyl chloride → 1,2,3,4-Tetrahydro-1-methoxymethyl-6,7-dimethoxyisoquinoline

반응식

[CH:1]1([CH:4]2[C:13]3[C:8](=[CH:9][C:10]([O:16][CH3:17])=[C:11]([O:14][CH3:15])[CH:12]=3)[CH2:7][CH2:6][NH:5]2)CC1.[CH3:18][O:19]CC(Cl)=O.C1(C(Cl)=O)CC1>>[CH3:18][O:19][CH2:1][CH:4]1[C:13]2[C:8](=[CH:9][C:10]([O:16][CH3:17])=[C:11]([O:14][CH3:15])[CH:12]=2)[CH2:7][CH2:6][NH:5]1

참가 물질

반응물 3

HCID 77637Cyclopropanecarbonyl chloride

HCID 96623Methoxyacetyl chloride

HCID 196102151-Cyclopropyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

생성물 1

HCID 196102831,2,3,4-Tetrahydro-1-methoxymethyl-6,7-dimethoxyisoquinoline

실험 절차

1,2,3,4-Tetrahydro-1-methoxymethyl-6,7-dimethoxyisoquinoline was prepared by a procedure analogous to that described in example 4 for 1,2,3,4-tetrahydro-1-cyclopropyl- 6,7-dimethoxy-isoquinoline but substituting in the first step 2-methoxyacetyl chloride for cyclopropylcarbonyl chloride.

출처 및 근거

ORD 기록: ord-f1beabbdaf5c48ab86a7f27c06a1b0fd
출처 데이터셋: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05981521

반응 노트

불러오는 중…