Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N,O-Dimethylhydroxylamine → N-Methoxy-N-methylquinoline-6-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N,O-Dimethylhydroxylamine | HCID 14232 | — |
| 반응물 | 6-Quinolinecarboxylic acid | HCID 82571 | — |
| 반응물 | Bis-(1H-imidazol-2-YL)-methanone | HCID 5250894 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-Methoxy-N-methylquinoline-6-carboxamide | HCID 55211172 | 97% |
반응 단계
To a solution of quinoline-6-carboxylic acid (10 g, 57.75 mmol) in DMF (200 mL) was added carbonyl diimidazole (10.3 g, 62.5 mmol) under nitrogen. The reaction was stirred for 1 hour. To the solution was added N,O-dimethyl hydroxylamine (5.6 g, 57.75 mmol), and the reaction was stirred at ambient temperature for 16 hours. The reaction was diluted with EtOAc (150 mL) and water (150 mL). The organic layer was separated, and the aqueous layer was extracted with EtOAc (5×100 mL). The organics were combined and washed with water (3×100 mL), brine (2×100 mL), dried over Na2SO4, filtered and concentrated to give quinoline-6-carboxylic acid methoxy-methyl-amide (11.97 g, 97% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732604B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-62bc40f4074643f5a8f11e7706291891 |
| 출처 메모 | uspto-grants-2010_06 |