HCID 178484264, 화합물 → HCID 178484262, 화합물

HRID 1602250

반응식

HRID 1602250 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:14]([C:15]#[N:16])=[C:13]([N:17]=[CH:18][N:19]([CH3:21])[CH3:20])[NH:12][N:11]=2)=[CH:6][CH:5]=1)([O-])=O>C1COCC1.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:14]([C:15]#[N:16])=[C:13]([N:17]=[CH:18][N:19]([CH3:21])[CH3:20])[NH:12][N:11]=2)=[CH:6][CH:5]=1

참가 물질

4

반응물 1

HCID 178484264HCID 178484264, 화합물

생성물 1

HCID 178484262HCID 178484262, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

In the presence of 30 mg of Pd/C (5%), 142 mg (0.50 mmol) of N'-[3-(4-nitro-phenyl)-4-cyano-1H-pyrazol-5-yl]-N,N-dimethylformamidine are hydrogenated in 20 ml of THF. Filtering, concentration by evaporation and crystallization from ethyl acetate/diethyl ether/hexane yield N'-[3-(4-amino-phenyl)-4-cyano-1H-pyrazol-5-yl]-N,N-dimethylformamidine; TLC: Rf =0.07 (ethyl acetate:hexane=3:1); FAB-MS: (M+H)+ =255.

후처리

  1. filtrationFiltering
  2. concentrationconcentration
  3. customby evaporation and crystallization from ethyl acetate/diethyl ether/hexane

출처 및 근거

ORD 기록
ord-aaa5dd31487e4c4e8c558a0038724872
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05981533

연결된 노트

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