(E)-3-(7-Chloro-benzofuran-4-yl)-acrylonitrile → 3-(2,3-Dihydro-benzofuran-4-yl)-propylamine hydrochloride

HRID 1602382노트

반응식

HRID 1602382 반응식
[Cl:1][C:2]1[C:10]2[O:9][CH:8]=[CH:7][C:6]=2[C:5](/[CH:11]=[CH:12]/[C:13]#[N:14])=[CH:4][CH:3]=1>C(O)(=O)C.[Pd]>[ClH:1].[O:9]1[C:10]2[CH:2]=[CH:3][CH:4]=[C:5]([CH2:11][CH2:12][CH2:13][NH2:14])[C:6]=2[CH2:7][CH2:8]1

참가 물질

4

반응물 1

HCID 19611650(E)-3-(7-Chloro-benzofuran-4-yl)-acrylonitrile2회

생성물 1

HCID 196116703-(2,3-Dihydro-benzofuran-4-yl)-propylamine hydrochloride

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

A solution of the (E)-3-(7-chloro-benzofuran-4-yl)-acrylonitrile (intermediate 3) (1.0 g) in acetic acid (30 ml) containing 10% palladium on charcoal (50 mg; 50% wet paste) and 5% platinium on charcoal (50 mg) was hydrogenated at 100 psi and 50° for 3 days. The solution was filtered through hyflo and evaporated to dryness and the residue recrystallised from isopropanol to give the title compound as white plates (583 mg).

후처리

  1. filtrationThe solution was filtered through hyflo
  2. customevaporated to dryness
  3. customthe residue recrystallised from isopropanol

출처 및 근거

ORD 기록
ord-6f0510d0d41143988681b54c9514f5c0
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05981572

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