Chlorosuccinimide → 3-(5-Chloro-2,3-dihydro-benzofuran-4-yl)propylamine hydrochloride

HRID 1602397노트

반응식

HRID 1602397 반응식
[ClH:1].[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH2:11][CH2:12][CH2:13][NH2:14])[C:5]=2[CH2:4][CH2:3]1.[Cl:15]N1C(=O)CCC1=O>C(O)(=O)C>[ClH:15].[Cl:1][C:9]1[CH:8]=[CH:7][C:6]2[O:2][CH2:3][CH2:4][C:5]=2[C:10]=1[CH2:11][CH2:12][CH2:13][NH2:14]

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 196116703-(2,3-Dihydro-benzofuran-4-yl)-propylamine hydrochloride

생성물 1

HCID 196116663-(5-Chloro-2,3-dihydro-benzofuran-4-yl)propylamine hydrochloride수율 91.3%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of of 3-(2,3-dihydro-benzofuran-4-yl)-propylamine hydrochloride (150 mg) and N-chlorosuccinimide (100 mg) in acetic acid (50 ml) was stirred at room temperature overnight. The solution was evaporated to dryness and the residue taken up in water, basified with 2N sodium hydroxide and extracted with dichloromethane. The extracts were dried and evaporated and the residue disolved in a solution of hydrogen chloride in methanol. Evaporation gave the the title compound (159 mg) as an off-white powder after trituration with ether.

후처리

  1. customThe solution was evaporated to dryness
  2. extractionextracted with dichloromethane
  3. customThe extracts were dried
  4. customevaporated
  5. customEvaporation

출처 및 근거

ORD 기록
ord-63f4c3f878b44de49201f7f2c813e6b7
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05981572

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