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Triethylamine → Cyclopropane carboxylic acid [3-(5-chloro-2,3-dihydro-benzofuran-4-yl)propyl]-amide

HRID 1602417
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인쇄 미리보기

반응식

HRID 1602417 반응식
Cl.[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][CH2:9][CH2:8][C:7]=2[C:11]=1[CH2:12][CH2:13][CH2:14][NH2:15].C(N(CC)CC)C.[CH:23]1([C:26](Cl)=[O:27])[CH2:25][CH2:24]1>CN(C)C=O.ClCCl>[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][CH2:9][CH2:8][C:7]=2[C:11]=1[CH2:12][CH2:13][CH2:14][NH:15][C:26]([CH:23]1[CH2:25][CH2:24]1)=[O:27]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 77637Cyclopropanecarbonyl chlorideHCID 196116663-(5-Chloro-2,3-dihydro-benzofuran-4-yl)propylamine hydrochloride

생성물 1

HCID 44214322Cyclopropane carboxylic acid [3-(5-chloro-2,3-dihydro-benzofuran-4-yl)propyl]-amide수율 50%

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매
HCID 6344
Dichloromethane
용매

실험 절차

A mixture of 3-(5-chloro-2,3-dihydro-benzofuran-4-yl)-propylamine hydrochloride (142 mg), dimethylformamide (5 drops), triethylamine (0.64 ml) and dichloromethane (5 ml) was stirred in ice for 20 minutes. Cyclopropanecarbonyl chloride (66 mg) was added and stirring continued for 5 hours. The mixture was purified by chromatography on silica eluting with ethyl acetate/hexane (1:1) to give the title compound as a white solid (80 mg).

후처리

  1. stirringstirring
  2. waitcontinued for 5 hours
  3. customThe mixture was purified by chromatography on silica eluting with ethyl acetate/hexane (1:1)

출처 및 근거

ORD 기록
ord-7822fb39f01a40358320921f4a1202ae
출처 데이터셋
uspto-grants-1999_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05981572

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