Methyl benzofuran-7-carboxylate → Benzofuran-7-ylmethanol

HRID 1602443노트

반응식

HRID 1602443 반응식
[O:1]1[C:5]2[C:6]([C:10](OC)=[O:11])=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[O:1]1[C:5]2[C:6]([CH2:10][OH:11])=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1

참가 물질

4

반응물 2

HCID 14229730Methyl benzofuran-7-carboxylateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 18787422Benzofuran-7-ylmethanol수율 91%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of methyl benzofuran-7-carboxylate (5.34 g, 30 mmol) was added to a suspension of LAH (2.31 g, 61 mmol) in THF and then heated to reflux for 30 min. The reaction was quenched with ethyl acetate and water. The mixture was made acidic with 12N HCl until all the precipitate dissolved. The ethyl acetate layer was separated, washed with water, dried with brine, and concentrated in vacuo to give a yellow oil (4.03 g, 91%).

후처리

  1. temperatureheated
  2. temperatureto reflux for 30 min
  3. customThe reaction was quenched with ethyl acetate and water
  4. dissolutiondissolved
  5. customThe ethyl acetate layer was separated
  6. washwashed with water
  7. dry with materialdried with brine
  8. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-c1ff4e68e9c840dabb6e9364425ef5d7
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05981571

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