1-Cyclopropylethanol → 3-(1-cyclopropylethoxy)-4-hydroxy-2(5H)-furanone

HRID 1602548

반응식

HRID 1602548 반응식
[N+](=[C:3]1[C:7](=[O:8])[CH2:6][O:5][C:4]1=[O:9])=[N-].[CH3:10][CH:11]([CH:13]1[CH2:15][CH2:14]1)[OH:12]>C([O-])(=O)C.[Rh+3].C([O-])(=O)C.C([O-])(=O)C>[CH:13]1([CH:11]([O:12][C:3]2[C:4](=[O:9])[O:5][CH2:6][C:7]=2[OH:8])[CH3:10])[CH2:15][CH2:14]1

참가 물질

4

반응물 2

HCID 791041-CyclopropylethanolHCID 154391133-Diazofuran-2,4-dione

생성물 1

HCID 701064543-(1-cyclopropylethoxy)-4-hydroxy-2(5H)-furanone

시약·촉매·용매 1

HCID 168478Rhodium acetate촉매

반응 조건

온도
130 °C

실험 절차

To the mixture of 3-diazo-2,4-(3H, 5H)-furandione (300 mg, 2.38 mmol; Example 207, Step 1) and α-methylcyclopropanemethanol (2.0 mL) was added rhodium acetate (30 mg). The mixture was heated at 130° C. for a period of 18 h. The excess of alcohol was evaporated under reduced pressure and the resulting crude mixture was purified by flash chromatography (10% to 20% MeOH in CH2Cl2) to provide 50 mg of the title compound.

후처리

  1. customThe excess of alcohol was evaporated under reduced pressure
  2. customthe resulting crude mixture was purified by flash chromatography (10% to 20% MeOH in CH2Cl2)

출처 및 근거

ORD 기록
ord-1ad36e16705846fbb2bf4c5139b3d46a
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05981576

연결된 노트

불러오는 중…