Methyl formate → Nalpha-formyl-DL-methionine amide

HRID 1602756노트

반응식

HRID 1602756 반응식
[NH2:1][CH:2]([C:7]([NH2:9])=[O:8])[CH2:3][CH2:4][S:5][CH3:6].[CH:10](OC)=[O:11]>>[CH:10]([NH:1][CH:2]([C:7]([NH2:9])=[O:8])[CH2:3][CH2:4][S:5][CH3:6])=[O:11]

참가 물질

3

반응물 2

HCID 7865Methyl formateHCID 5687422-Amino-4-(methylthio)butanamide

생성물 1

HCID 18329562Nalpha-formyl-DL-methionine amide수율 55%

실험 절차

30 g (0.20 mole) DL-methionine amide were agitated with 250 ml methyl formate for two days at room temperature, during which fine, slightly yellow crystals developed. They were filtered off and recrystallized out of a mixture of 150 ml hexane and 160 ml ethanol. After cooling off, filtering, washing and drying, 23 g (55%) Nα -formyl-DL-methionine amide were obtained in the form of colorless crystals with a melting point of 121-122° C.

후처리

  1. filtrationThey were filtered off
  2. customrecrystallized out of a mixture of 150 ml hexane and 160 ml ethanol
  3. temperatureAfter cooling off
  4. filtrationfiltering
  5. washwashing
  6. customdrying

출처 및 근거

ORD 기록
ord-2bfbf8db1e2b4e1da89df3c38f14a767
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05985632

반응 노트

불러오는 중…