Water → Timolol Maleate

HRID 1603402

반응식

HRID 1603402 반응식
[CH3:1][CH2:2][CH:3]([C:5]([OH:7])=[O:6])C.[CH3:8][C:9]([NH:12][CH2:13][C@H:14]([OH:28])[CH2:15][O:16][C:17]1[C:18]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[N:19][S:20][N:21]=1)([CH3:11])[CH3:10].[OH2:29]>C([O-])(=O)C.[Zn+2].C([O-])(=O)C>[CH3:11][C:9]([NH:12][CH2:13][C@H:14]([OH:28])[CH2:15][O:16][C:17]1[C:18]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[N:19][S:20][N:21]=1)([CH3:8])[CH3:10].[CH:3](/[C:5]([OH:7])=[O:6])=[CH:2]/[C:1]([OH:16])=[O:29]

참가 물질

5

반응물 3

HCID 962Water2회HCID 83142-Methylbutanoic AcidHCID 33624Timolol

생성물 1

HCID 5281056Timolol Maleate

시약·촉매·용매 1

HCID 11192Zinc Acetate촉매

실험 절차

15 grams of Carbopol 974P is dispersed in 40 grams of heavy mineral oil USP and is added to 841.5 grams of water containing 2.5 grams of timolol meleate with vigorous stirring. 100 grams of water containing 1.0 gram of zinc acetate is added in a controlled fashion with homogenization to get a particle size distribution size below 5 micron.

후처리

  1. customto get a particle size distribution size below 5 micron

출처 및 근거

ORD 기록
ord-9cca235f36404870a5655411ed51d3e0
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05989535

연결된 노트

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