HCID 19605759, 화합물 → 6-[2-(2,5-Dimethoxyphenyl)ethyl]-4-ethyl-quinazoline

HRID 1603527노트

반응식

HRID 1603527 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11]#[C:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[CH:18][N:17]=[C:16]2[CH2:23][CH3:24]>C(OCC)(=O)C.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[CH2:11][CH2:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[CH:18][N:17]=[C:16]2[CH2:23][CH3:24]

참가 물질

4

반응물 1

HCID 19605759HCID 19605759, 화합물

생성물 1

HCID 99490646-[2-(2,5-Dimethoxyphenyl)ethyl]-4-ethyl-quinazoline

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

150 mg of 6-[2-(2,5-dimethoxyphenyl)ethynyl]-4-ethyl-quinazoline are dissolved in 10 ml of ethyl acetate. After addition of 20 mg of palladium (10% on charcoal) the mixture is stirred overnight under an atmosphere of hydrogen and subsequently filtered over celite. The filtrate is evaporated in vacuo and the residue crystallised from cylohexane to obtain the title compound as colourless crystals. mp: 74°.

후처리

  1. filtrationsubsequently filtered over celite
  2. customThe filtrate is evaporated in vacuo
  3. customthe residue crystallised from cylohexane

출처 및 근거

ORD 기록
ord-cc9ba045d0294a579aae97e17a56de20
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05990116

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