Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-butyl N-(4-aminobutyl)carbamate → 1-(4-N-Boc-aminobutyl)-1H-pyrrole-2,5-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-butyl N-(4-aminobutyl)carbamate | HCID 4351 | — |
| 반응물 | Maleic Anhydride | HCID 7923 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 1-(4-N-Boc-aminobutyl)-1H-pyrrole-2,5-dione | HCID 59709139 | — |
반응 단계
To a solution of N-BOC-1,4-diaminobutane (8.324 g, 0.044 mol) in dry toluene (50 ml) was added maleic anhydride (4.336 g, 0.044 mol) and the solution heated at reflux under Dean-Stark conditions for two days. The solvent was removed and the residue purified by silica column chromatography eluting with 25-40% ethyl acetate in hexane to give the title compound, 1.461 g, 12%, as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07736635B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-5f8e5d07e27c4cbb8e72a0fb83256796 |
| 출처 메모 | uspto-grants-2010_06 |