Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Methoxy-6-(trifluoromethyl)indoline → 5-Methoxy-6-trifluoromethyl-1-[4-(pyridin-4-ylthiomethyl)phenyl Carbamoyl]indoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Methoxy-6-(trifluoromethyl)indoline | HCID 11206713 | — |
| 반응물 | Benzenamine, 4-[(4-pyridinylthio)methyl]- | HCID 18005148 | — |
| 반응물 | Phenylcarbamate | HCID 21896570 | — |
| 생성물 | 5-Methoxy-6-trifluoromethyl-1-[4-(pyridin-4-ylthiomethyl)phenyl Carbamoyl]indoline | HCID 18005150 | 64% |
반응 단계
4-(Pyridin-4-ylthiomethyl)aniline (0.37 g, 1.71 mmol) was converted to the phenylcarbamate and treated with 5-methoxy-6-trifluoromethylindoline (D111) (0.37 g, 1.71 mmol) as in the method of Example 26 to give the title compound (0.5 g, 64%) as a white crystalline solid m.p. 174-5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05990133 |
| 출처 데이터셋 | uspto-grants-1999_11 |
| ORD ID | ord-9d08a06f7a7546d8b42c091e0a6c4797 |
| 출처 메모 | uspto-grants-1999_11 |