2,3-Dimethoxybenzaldehyde → 1-(2,3-Dimethoxyphenyl)ethanol
반응식
[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=[O:6].[CH3:13][Mg]Br>C(OCC)C>[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]([OH:6])[CH3:13]참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
A solution of 2,3-dimethoxybenzaldehyde (10.0 g, 60.2 mmol) in dry ethyl ether (100 ml) was added at 0° C. with a 3M solution of methylmagnesium bromide in ethyl ether (35 ml) and left under stirring at 0° C. for 0.5 h. Afterwards the reaction mixture was added with a diphasic mixture of ethyl ether and an ammonium chloride saturated solution, extracting the aqueous phase with ethyl ether. The organic extracts were dried and the solvent was evaporated off under reduced pressure, thereby obtaining 10.06 g of the title compound (92% yield).
후처리
- waitleft
- extractionan ammonium chloride saturated solution, extracting the aqueous phase with ethyl ether
- customThe organic extracts were dried
- customthe solvent was evaporated off under reduced pressure
출처 및 근거
- ORD 기록
- ord-a717c936a7ac49008a804e86032e9f27
- 출처 데이터셋
- uspto-grants-1999_11
- 특허 번호
- US05990142
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